Article
Role of association of OmpK35 and OmpK36 alteration and blaESBL and/or blaAmpC genes in conferring carbapenem resistance among non-carbapenemase-producing Klebsiella pneumoniae.
International journal of antimicrobial agents - 1 Dec 2018
Hamzaoui Zaineb, Ocampo-Sosa Alain, Fernandez Martinez Marta, Landolsi Sarrah, Ferjani Sana, Maamar Elaa, Saidani Mabrouka, Slim Amine, Martinez-Martinez Luis, Boutiba-Ben Boubaker Ilhem
Abstract excerpt
In Klebsiella pneumoniae, loss of the two major outer membrane porins (OMPs) OmpK35 and OmpK36 confers resistance to carbapenems in strains producing extended-spectrum β-lactamases (ESBLs) or plasmid-mediated AmpC-type β-lactamases. This study investigated mechanisms responsible for carbapenem resistance in non-carbapenemase-producing K. pneumoniae (NCPK). All carbapenem-resistant Enterobacteriaceae (CRE) at...
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