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The RNA binding protein Nab2 regulates splicing of the RhoGEF <i>trio</i> transcript to govern axon and dendrite morphology

2024-04-06

Abstract excerpt

<h4>ABSTRACT</h4> The Drosophila RNA binding protein (RBP) Nab2 acts in neurons to regulate neurodevelopment and is orthologous to the human intellectual disability-linked RBP, ZC3H14. Nab2 governs axon projection in mushroom body neurons and limits dendritic arborization of class IV sensory neurons in part by regulating splicing events in ~150 mRNAs. Analysis of the Sex-lethal ( Sxl ) mRNA revealed that Nab2...

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Literature Corpus work
366b6804-a3c3-5544-b6be-0377068c27c7
DOI
10.1101/2024.04.05.588324
Open publication

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