Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition.

Genome biology - 12 May 2015

Laver John D, Li Xiao, Ray Debashish, Cook Kate B, Hahn Noah A, Nabeel-Shah Syed, Kekis Mariana, Luo Hua, Marsolais Alexander J, Fung Karen Yy, Hughes Timothy R, Westwood J Timothy, Sidhu Sachdev S, Morris Quaid, Lipshitz Howard D, Smibert Craig A

Abstract excerpt

BACKGROUND: Brain tumor (BRAT) is a Drosophila member of the TRIM-NHL protein family. This family is conserved among metazoans and its members function as post-transcriptional regulators. BRAT was thought to be recruited to mRNAs indirectly through interaction with the RNA-binding protein Pumilio (PUM). However, it has recently been demonstrated that BRAT directly binds to RNA. The precise sequence recognized by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila

Share to Drosophila Proteins

Share to Gene Expression Regulation, Developmental

Share to Nuclear Proteins

Share to RNA-Binding Proteins

Share to Tissue Culture Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 25962635
DOI: 10.1186/s13059-015-0659-4
PMCID: PMC4460960

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition.PMID 25962635Read ↗

The RNA-binding activity of the Drosophila Brat protein is necessary for viability and mRNA regulation.Semantic proximity Read ↗

The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.Semantic proximity Read ↗

Drosophila Brain Tumor is a translational repressor.Semantic proximity Read ↗

BCL11b interacts with RNA and proteins involved in RNA processing and developmental diseasesSemantic proximity Read ↗

Systematic Analysis of Targets of Pumilio (PUM)-Mediated mRNA Decay Identifies a Role of PUM1 in Regulating DNA Damage Response PathwaySemantic proximity Read ↗

Transcriptional signature of an adult brain tumor in Drosophila.Semantic proximity Read ↗

A Novel Mutation in Brain Tumor Causes Both Neural Over-Proliferation and Neurodegeneration in Adult Drosophila.Semantic proximity Read ↗

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptomeSemantic proximity Read ↗

Identification of Two Novel Proteins That Interact with Germ-Cell-Specific RNA-Binding Proteins DAZ and DAZL1Semantic proximity Read ↗

Identification of Specialized tRNA Expression in Early Human Brain DevelopmentSemantic proximity Read ↗

Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammalsSemantic proximity Read ↗

The polyadenosine RNA binding protein Nab2 regulates alternative splicing and intron retention during <i>Drosophila melanogaster</i> brain developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.