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Article

Genetic analysis of brahma: the Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2.

Genetics - 1 Jan 1998

Elfring L K, Daniel C, Papoulas O, Deuring R, Sarte M, Moseley S, Beek S J, Waldrip W R, Daubresse G, DePace A, Kennison J A, Tamkun J W

Abstract excerpt

The Drosophila brahma (brm) gene encodes an activator of homeotic genes related to the yeast chromatin remodeling factor SWI2/SNF2. Here, we report the phenotype of null and dominant-negative brm mutations. Using mosaic analysis, we found that the complete loss of brm function decreases cell viability and causes defects in the peripheral nervous system of the adult. A dominant-negative brm mutation was generated...

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Identifiers

PMID: 9475737
DOI: 10.1093/genetics/148.1.251
PMCID: PMC1459776

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Research trail→

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Genetic analysis of brahma: the Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2.PMID 9475737Read ↗

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.Semantic proximity Read ↗

SNR1 is an essential subunit in a subset of Drosophila brm complexes, targeting specific functions during development.Semantic proximity Read ↗

Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).Semantic proximity Read ↗

Genetic screens for enhancers of brahma reveal functional interactions between the BRM chromatin-remodeling complex and the delta-notch signal transduction pathway in Drosophila.Semantic proximity Read ↗

Characterization of a Brg1 hypomorphic allele demonstrates that genetic and biochemical activity are tightly correlated.Semantic proximity Read ↗

Hormone-response genes are direct in vivo regulatory targets of Brahma (SWI/SNF) complex function.Semantic proximity Read ↗

A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development.Semantic proximity Read ↗

Essential Role of ARID2 Protein-containing SWI/SNF Complex in Tissue-specific Gene ExpressionSemantic proximity Read ↗

BRM: the core ATPase subunit of SWI/SNF chromatin-remodelling complex—a tumour suppressor or tumour-promoting factor?Semantic proximity Read ↗

SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.Semantic proximity Read ↗

The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit.Semantic proximity Read ↗

The Drosophila Brahma (SWI/SNF) chromatin remodeling complex exhibits cell-type specific activation and repression functions.Semantic proximity Read ↗

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