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Article

The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.

Genes & development - 1 Apr 2014

Loedige Inga, Stotz Mathias, Qamar Saadia, Kramer Katharina, Hennig Janosch, Schubert Thomas, Löffler Patrick, Längst Gernot, Merkl Rainer, Urlaub Henning, Meister Gunter

Abstract excerpt

The Drosophila protein brain tumor (Brat) forms a complex with Pumilio (Pum) and Nanos (Nos) to repress hunchback (hb) mRNA translation at the posterior pole during early embryonic development. It is currently thought that complex formation is initiated by Pum, which directly binds the hb mRNA and subsequently recruits Nos and Brat. Here we report that, in addition to Pum, Brat also directly interacts with the hb...

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Identifiers

PMID: 24696456
DOI: 10.1101/gad.236513.113
PMCID: PMC4015489

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NCL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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