Article
Plants tolerate substantial rates of plastid mistranslation via regulated proteostasis.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jun 2026
Brandt Benjamin, Schwartz Sebastian, Schwenkert Serena, Krämer Moritz, Om Kuenzang, Engstler Carina, Klingl Andreas, Jahns Peter, Meyer Etienne H, DeTar Rachael A, Eirich Jürgen, Finkemeier Iris, Cousins Asaph B, Kunz Hans-Henning
Abstract excerpt
In bacteria, protein mistranslation can improve stress tolerance. Mitochondria and plastids evolved from bacteria and use a prokaryotic-type expression machinery to synthesize proteins. Interestingly, fungi and animal mitochondria are highly sensitive to mistranslation, which for instance manifests in lethal mitochondrial cardiomyopathy disorder. The response in plant cells is unknown. Glutaminyl-transfer RNAs...
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