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Article

Local genetic correlations between systemic sclerosis and common cancer types.

PloS one - 1 Jan 2026

Patasova Karina, Che Weng Ian, Westerlind Helga, Diaz-Gallo Lina Marcela, Holmqvist Marie

Abstract excerpt

INTRODUCTION: The incidence of cancer, encompassing all major types, is significantly higher among patients with systemic sclerosis (SSc) compared to the general population. While previous studies have assessed the global genetic relationships between SSc and various cancers and found no evidence of causality or pleiotropy, these methods average effects across the genome and thus ignore potential opposing...

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PMID: 42201917
DOI: 10.1371/journal.pone.0350006
PMCID: PMC13215533

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