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A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease.

Scientific reports - 5 Feb 2020

González-Serna David, Ochoa Eguzkine, López-Isac Elena, Julià Antonio, Degenhardt Frauke, Ortego-Centeno Norberto, Radstake Timothy R D J, Franke Andre, Marsal Sara, Mayes Maureen D, Martín Javier, Márquez Ana

Abstract excerpt

Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn's disease (CD), some of which confer susceptibility to both diseases. In order to identify new risk loci shared between these two immune-mediated disorders, we performed a cross-disease meta-analysis including GWAS data from 5,734 SSc patients, 4,588 CD patients and 14,568...

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Identifiers

PMID: 32024964
DOI: 10.1038/s41598-020-58741-w
PMCID: PMC7002703

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