Article

Cross-Phenotype GWAS Supports Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis

2024-07-03

Abstract excerpt

<h4>Objective</h4> An increased risk of primary biliary cholangitis (PBC) has been reported in patients with systemic sclerosis (SSc). Our study aims to investigate the shared genetic susceptibility between the two disorders and to define candidate causal genes using cross-phenotype GWAS meta-analysis. <h4>Methods</h4> We performed cross-phenotype GWAS meta-analysis and colocalization analysis for SSc and PBC. We...

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Literature Corpus work: 46456203-9c1e-50d2-a601-9aa5ff5a6193
DOI: 10.1101/2024.07.01.24309721

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