Expression Quantitative Trait Locus Analysis in Systemic Sclerosis Identifies New Candidate Genes Associated With Multiple Aspects of Disease Pathology.

doi:10.1002/art.41657

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Expression Quantitative Trait Locus Analysis in Systemic Sclerosis Identifies New Candidate Genes Associated With Multiple Aspects of Disease Pathology.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jul 2021

Kerick Martin, González-Serna David, Carnero-Montoro Elena, Teruel Maria, Acosta-Herrera Marialbert, Makowska Zuzanna, Buttgereit Anne, Babaei Sepideh, Barturen Guillermo, López-Isac Elena, Lesche Ralf, Beretta Lorenzo, Alarcon-Riquelme Marta E, Martin Javier

Abstract excerpt

OBJECTIVE: To identify the genetic variants that affect gene expression (expression quantitative trait loci [eQTLs]) in systemic sclerosis (SSc) and to investigate their role in the pathogenesis of the disease. METHODS: We performed an eQTL analysis using whole-blood sequencing data from 333 SSc patients and 524 controls and integrated them with SSc genome-wide association study (GWAS) data. We integrated our...

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PMID: 33455083
DOI: 10.1002/art.41657

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