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Article

Cross-Phenotype Genome-Wide Association Study on the Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2025

Luo Yiming, Khan Atlas, Liu Lili, Lee Cue Hyunkyu, Perreault Gabriel J, Pomenti Sydney F, Gourh Pravitt, Kiryluk Krzysztof, Bernstein Elana J

Abstract excerpt

OBJECTIVE: An increased risk of primary biliary cholangitis (PBC) has been reported in patients with systemic sclerosis (SSc). Our study aims to investigate the shared genetic susceptibility between the two disorders and to define candidate causal genes using cross-phenotype genome-wide association study (GWAS) meta-analysis. METHODS: We performed cross-phenotype GWAS meta-analysis and Bayesian colocalization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Liver Cirrhosis, Biliary

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Share to Polymorphism, Single Nucleotide

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Share to Scleroderma, Systemic

Source

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Identifiers

PMID: 39676709
DOI: 10.1002/art.43081
PMCID: PMC12124972

Genes

CD40
ERAP1
PLD4
SPPL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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