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Article

AKT2 Exon 3 Variants and Their Prevalence in Prostate Cancer Patients: Insights from a Jordanian Clinical Cohort.

International journal of molecular sciences - 9 May 2026

Rahahlah Nuseibah, Al-Alami Zina, Alorjani Mohammed S, Al-Smadi Asmaa, Obeidat Sewar, Otoom Raed, Al-Zoubi Raed M, Al Bashir Samir, Al Zoubi Mazhar Salim

Abstract excerpt

The AKT2 gene, located on chromosome 19, encodes a protein involved in key cellular processes like metabolism, proliferation, and survival. Abnormalities in the PI3K/AKT pathway, including AKT2, contribute to tumor progression. AKT2 promotes cell survival, growth, and resistance to therapy. Overexpression or hyperactivation of AKT2 is linked to prostate cancer (PC) development, making it a potential therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42196210
DOI: 10.3390/ijms27104228
PMCID: PMC13207545

Genes

AKT2
PC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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