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Article

E17K substitution in AKT1 in prostate cancer

20 Apr 2010

Abstract excerpt

BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)-AKT pathway is activated in many cancers. Mutational hotspots in AKT1 and in the regulatory and catalytic subunits of PI3K have been detected in multiple tumour types. In AKT1, the E17K substitution leads to a PI3K-independent activation of AKT1. METHODS: A mutational profiling of AKT1 and of the mutational hotspots in PIK3CA and PIK3R1 was carried out in...

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PMID: 20407443
DOI: 10.1038/sj.bjc.6605673

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