Article
A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.
Cancer cell - 12 Jun 2017
Zhang Yiqun, Kwok-Shing Ng Patrick, Kucherlapati Melanie, Chen Fengju, Liu Yuexin, Tsang Yiu Huen, de Velasco Guillermo, Jeong Kang Jin, Akbani Rehan, Hadjipanayis Angela, Pantazi Angeliki, Bristow Christopher A, Lee Eunjung, Mahadeshwar Harshad S, Tang Jiabin, Zhang Jianhua, Yang Lixing, Seth Sahil, Lee Semin, Ren Xiaojia, Song Xingzhi, Sun Huandong, Seidman Jonathan, Luquette Lovelace J, Xi Ruibin, Chin Lynda, Protopopov Alexei, Westbrook Thomas F, Shelley Carl Simon, Choueiri Toni K, Ittmann Michael, Van Waes Carter, Weinstein John N, Liang Han, Henske Elizabeth P, Godwin Andrew K, Park Peter J, Kucherlapati Raju, Scott Kenneth L, Mills Gordon B, Kwiatkowski David J, Creighton Chad J
Abstract excerpt
Molecular alterations involving the PI3K/AKT/mTOR pathway (including mutation, copy number, protein, or RNA) were examined across 11,219 human cancers representing 32 major types. Within specific mutated genes, frequency, mutation hotspot residues, in silico predictions, and functional assays were all informative in distinguishing the subset of genetic variants more likely to have functional relevance. Multiple...
Topics
- Databases, Genetic
- Gene Expression Profiling
- Humans
- Mutation
- Neoplasms
- Phosphatidylinositol 3-Kinases