Associations of genetic polymorphisms in pTEN/AKT/mTOR signaling pathway genes with cancer risk: A meta-analysis in Asian population.

doi:10.1038/s41598-017-17250-z

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Associations of genetic polymorphisms in pTEN/AKT/mTOR signaling pathway genes with cancer risk: A meta-analysis in Asian population.

Scientific reports - 19 Dec 2017

Zhang Zhen, Chen Qiuchen, Zhang Jing, Wang Yilin, Hu Xiaoyun, Yin Sainan, He Miao, Guan Shu, Qin Wenyan, Xiao Qinghuan, Zhao Haishan, Yao Weifan, Wu Huizhe, Wei Minjie

Abstract excerpt

The pTEN/AKT/mTOR signaling pathways play a critical role in balancing cell proliferation, differentiation, and survival. Recent studies researched the associations of core genes in the pTEN/AKT/mTOR pathway polymorphisms with the cancer susceptibility; however, the results are inconclusive. Therefore, a systematically meta-analysis was performed to evaluate the association between the five SNPs (mTOR rs2295080...

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PMID: 29259266
DOI: 10.1038/s41598-017-17250-z
PMCID: PMC5736732

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