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Article

Hypomethylation-driven AKT Serine/Threonine Kinase 3 promotes testicular germ cell tumors proliferation and negatively correlates to immune infiltration.

Bioengineered - 1 Dec 2021

Luo Yang, Zhou Qianyin, Zhu Fang, Fan Liqing, Bo Hao, Wang Xingming

Abstract excerpt

AKT Serine/Threonine Kinase 3 (AKT3) has been reported to play an important role in different tumors. However, its clinical value, biological function, and molecular mechanism in testicular germ cell tumors (TGCT) remains unclear. In the current study, we applied the Gene Set Cancer Analysis (GSCA), UCSC XENA, Gene Expression Omnibus (GEO), the Human Protein Atlas (HPA), LinkedOmics, DiseaseMeth version 2.0,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocytes, Tumor-Infiltrating

Share to Neoplasms, Germ Cell and Embryonal

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Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 34882061
DOI: 10.1080/21655979.2021.2002621
PMCID: PMC8810072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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