Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Droplet digital PCR assay for simultaneous detection of the ERG11 mutation and copy number variation associated with azole resistance in Candida tropicalis.

International journal of antimicrobial agents - 1 Sept 2026

Fan Xin, Wang Nan, Chen Xi, Tan Chianru, Liu Feiyi, Zhao Yiying, Guo Yong, Xiao Meng

Abstract excerpt

BACKGROUND: Azole resistance in Candida tropicalis has increased worldwide and is largely driven by an emerging population previously reported Cluster AZR/X. This cluster exhibits high-level azole resistance driven by ERG11 A395T/W mutations accompanied by amplification of mutant ERG11 alleles, underscoring the clinical need for a quantitative, mechanism-informed molecular assay. METHODS: We developed and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Azoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Candida tropicalis

Share to Cytochrome P-450 Enzyme System

Share to DNA Copy Number Variations

Share to Drug Resistance, Fungal

Share to Microbial Sensitivity Tests

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 42191006
DOI: 10.1016/j.ijantimicag.2026.107847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Droplet digital PCR assay for simultaneous detection of the ERG11 mutation and copy number variation associated with azole resistance in Candida tropicalis.PMID 42191006Read ↗

A Multiplex Droplet Digital PCR Assay for Chromosome Copy Number Determination in <i>Candida albicans</i>Semantic proximity Read ↗

Azole Resistance and ERG11 Mutation in Clinical Isolates of Candida tropicalisSemantic proximity Read ↗

Rapid Detection of Azole-Resistant Aspergillus fumigatus in Clinical and Environmental Isolates by Use of a Lab-on-a-Chip Diagnostic System.Semantic proximity Read ↗

Mechanisms of azole antifungal resistance in clinical isolates of Candida tropicalisSemantic proximity Read ↗

Laboratory-developed Droplet Digital PCR Assay for Quantification of the JAK2V617F MutationSemantic proximity Read ↗

Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing.Semantic proximity Read ↗

Advancing artemisinin resistance monitoring using a high sensitivity ddPCR assay for Pfkelch13 mutation detection in Asia.Semantic proximity Read ↗

High-sensitivity KIT D816V variation analysis by droplet digital polymerase chain reaction: The reference laboratory perspective.Semantic proximity Read ↗

Single-cell detection of copy number changes reveals dynamic mechanisms of adaptation to antifungals in Candida albicans.Semantic proximity Read ↗

Copy Number Variation and Allele Ratio Analysis in Candida albicans Using Whole Genome Sequencing Data.Semantic proximity Read ↗

Azole Resistance in Candida albicans Isolates from Oropharyngeal Candidiasis is Associated with ERG11 Mutation and Efflux OverexpressionSemantic proximity Read ↗

Validation of Single-Nucleotide Mosaic Variants Through Droplet Digital PCR.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.