Azole Resistance and ERG11 Mutation in Clinical Isolates of Candida tropicalis

Abstract excerpt

We investigated the molecular mechanisms underlying azole resistance in seven Candida tropicalis isolates that caused candidemia and candiduria in Paraná, Brazil (2016–2022). Biofilm production, antifungal susceptibility testing, multilocus sequence typing, amplification and sequencing of ERG11, and quantification of ERG11, MDR1, and CDR1 expression levels were performed. Notably, five isolates (71.4%) were from...

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• Antifungal resistance and susceptibility
• Fungal Infections and Studies
• Pneumocystis jirovecii pneumonia detection and treatment