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Article

Advancing artemisinin resistance monitoring using a high sensitivity ddPCR assay for Pfkelch13 mutation detection in Asia.

Scientific reports - 10 Feb 2025

Srisutham Suttipat, Saejeng Aungkana, Khantikul Nardlada, Sugaram Rungniran, Sangsri Raweewan, Dondorp Arjen M, Day Nicholas P J, Imwong Mallika

Abstract excerpt

The spread of Pfkelch13 mutations in Southeast Asia threatens the effectiveness of artemisinin-based combination therapies (ACTs) for malaria. Previous studies revealed a high prevalence of key mutations, including C580Y, P574L, and R561H, emphasizing the need for the surveillance to combat drug resistance. This study, we developed a droplet digital PCR (ddPCR) assay for the rapid screening of common mutations...

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Identifiers

PMID: 39929914
DOI: 10.1038/s41598-025-86630-7
PMCID: PMC11811204

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