Article
Copy Number Variation and Allele Ratio Analysis in Candida albicans Using Whole Genome Sequencing Data.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023
Todd Robert T, Selmecki Anna
Abstract excerpt
Whole genome sequencing of human fungal pathogens has revolutionized the speed and accuracy in which sequence variants that cause antifungal resistance can be identified. Genome rearrangements resulting in copy number variation (CNV) are a significant source of acquired antifungal drug resistance across diverse fungal species. Some CNVs are transient in nature, while other CNVs are stable and well tolerated even...
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