Article
Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing.
BMC microbiology - 14 Aug 2009
Wang Huiping, Kong Fanrong, Sorrell Tania C, Wang Bin, McNicholas Paul, Pantarat Namfon, Ellis David, Xiao Meng, Widmer Fred, Chen Sharon Ca
Abstract excerpt
BACKGROUND: Amino acid substitutions in the target enzyme Erg11p of azole antifungals contribute to clinically-relevant azole resistance in Candida albicans. A simple molecular method for rapid detection of ERG11 gene mutations would be an advantage as a screening tool to identify potentially-res...
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