Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin enables acquisition of the IL7R+ memory phenotype in PD1+ T cells in RA tissues.

Cell death & disease - 25 May 2026

Chandrasekaran Venkataragavan, Erlandsson Malin C, Svensson David, Malmhäll-Bah Eric, Silfverswärd Sofia Töyrä, Pullerits Rille, Katona Gergely, Bokarewa Maria I

Abstract excerpt

Insulin signaling regulates cellular metabolism in an epigenetic manner, but its role in the immune cell homeostasis remains unknown. High plasma insulin obstructs efficient insulin signaling and rewires metabolic activity in autoimmunity. In this study, we explored the functional consequences of insulin signaling for the metabolism and phenotype of effector CD4+ T cells in blood and synovial tissue of patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to Histones

Share to Immunologic Memory

Share to Programmed Cell Death 1 Receptor

Share to Receptors, Interleukin-7

Share to Synovial Membrane

Source

Open in PubMed Open full text

Identifiers

PMID: 42185247
DOI: 10.1038/s41419-026-08916-6
PMCID: PMC13201554

Genes

CD4
IL7R
BCL2
CD27
CTLA4
IL7
STAT5A
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin enables acquisition of the IL7R+ memory phenotype in PD1+ T cells in RA tissues.PMID 42185247Read ↗

Insulin exerts epigenetic control of joint-specific memory T cells in rheumatoid arthritisSemantic proximity Read ↗

Hyperinsulinemia counteracts inflammation by suppressing IFNγ and inducing senescence in CD4<sup>+</sup>T cells of patients with rheumatoid arthritisSemantic proximity Read ↗

Islet Lymphocytes Maintain a Stable Regulatory Phenotype Under Homeostatic Conditions and Metabolic Stress.Semantic proximity Read ↗

Elevated histone H3 acetylation is associated with genes involved in T lymphocyte activation and glutamate decarboxylase antibody production in patients with type 1 diabetesSemantic proximity Read ↗

LRH-1/NR5A2 Activation Rewires Immunometabolism Blunting Inflammatory Immune Cell Progression in Individuals with Type 1 Diabetes and Enhances Human Islet Function in MiceSemantic proximity Read ↗

Reduction of pro-inflammatory effector functions through remodeling of fatty acid metabolism in CD8<sup>+</sup> T-cells from Rheumatoid Arthritis patientsSemantic proximity Read ↗

Pharmacological HDAC inhibition impairs pancreatic β-cell function through an epigenome-wide reprogrammingSemantic proximity Read ↗

TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositisSemantic proximity Read ↗

Fatty Acid Oxidation Promotes Apoptotic Resistance and Proinflammatory Phenotype of CD4+ Tissue-resident Memory T cells in Crohn's Disease.Semantic proximity Read ↗

Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs.Semantic proximity Read ↗

Phenylalanine Impairs Insulin Signaling and Inhibits Glucose Uptake by Modifying IRβSemantic proximity Read ↗

Polyamine metabolism is a central determinant of helper T cell lineage fidelitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.