Article

Insulin exerts epigenetic control of joint-specific memory T cells in rheumatoid arthritis

2025-04-07

Abstract excerpt

<h4>Background</h4> Insulin has epigenetic effect influencing gene expression. High peripheral insulin concentrations promote insulin resistance in autoimmunity. Oncoprotein survivin/ BIRC5 modulates glucose metabolism through chromatin binding and propagates IFNg effects in CD4 + cells. In this study, we explored how insulin influences chromatin binding and metabolic activity in autoimmune CD4 + cells of pati...

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Literature Corpus work: bcefc322-ccbc-51fb-811c-bf80ba1c52f5
DOI: 10.1101/2025.04.01.646580

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