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Article

Post-Stroke Depression Is Associated With Shared Neurodevelopmental Risk and Circuit Disruption.

Brain and behavior - 1 May 2026

Xu Zhi-Jie, Zhang Su-Xiang, Li Ji-Ling, Wu Jia-Jia, Ma Jie, Ma Zhen-Zhen, Tao Ji-Ming, Hua Xu-Yun, Xu Jian-Guang

Abstract excerpt

INTRODUCTION: Post-stroke depression (PSD) affects approximately 30% of stroke survivors and worsens functional outcomes, yet its biological basis remains poorly understood. METHODS: We integrated cross-disorder genomics, developmental spatial transcriptomics, and causal neuroimaging in 16 PSD patients and 14 matched controls. Polygenic overlap was quantified using MiXeR and conditional FDR (condFDR). Shared risk...

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Identifiers

PMID: 42178876
DOI: 10.1002/brb3.71502
PMCID: PMC13239996

Genes

PSD
HDAC9
PITX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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