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Article

Shared Genetic Liability and Causal Associations Between Major Depressive Disorder and Cardiovascular Diseases

11 Nov 2021

Abstract excerpt

Major depressive disorder (MDD) is phenotypically associated with cardiovascular diseases (CVD). We aim to investigate mechanisms underlying relationships between MDD and CVD in the context of shared genetic variations. Polygenic overlap analysis was used to test genetic correlation and to analyze shared genetic variations between MDD and seven cardiovascular outcomes (coronary artery disease (CAD), heart...

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PMID: 34859065
DOI: 10.3389/fcvm.2021.735136

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