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Article

Genetic and epigenetic architectures of stroke: Insights from GWAS to precision medicine.

Neurochemistry international - 1 Nov 2025

Shehjar Faheem, Mahajan Reetika, Shahnaz Shayaan, Shah Zahoor A

Abstract excerpt

Stroke remains a leading cause of death and disability, driven by complex interactions among genetic, epigenetic, and environmental factors. Advances in genomic technologies have elucidated the role of common polygenic variants and rare monogenic mutations in determining susceptibility to stroke subtypes. Genome-wide association studies have identified key loci, including Histone Deacetylase 9 (HDAC9),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41005670
DOI: 10.1016/j.neuint.2025.106059
PMCID: PMC13261748

Genes

COL4A1
CYP2C19
GLA
HBB
HDAC9
NOTCH3
PITX2
SCD
SLCO1B1
VKORC1
ZFHX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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