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A genomic structural equation modelling study elucidates shared genetic architecture of polygenic traits associated with post-intensive care syndrome.

Scientific reports - 1 Apr 2026

Lv Quankun, Wu Guoxin, Huang Zihao, Huo Jiaxian, Huang Xinming, Yang Bin, Ye Yi, Cai Yanglin, Chen Shengan, Chen Long, Guan Ziyun, Liu Zhiyu

Abstract excerpt

Post-intensive care syndrome (PICS) is defined by persistent psychological, cognitive and physical impairments after critical illness, yet its shared genetic basis remains unknown. We applied genomic structural equation modeling (Genomic SEM) to large-scale GWAS summary statistics for major depressive disorder (N = 217,584), post-traumatic stress disorder (N = 199,213), cognitive function (N = 257,841), memory...

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PMID: 41922593
DOI: 10.1038/s41598-026-45594-y
PMCID: PMC13187156

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CACNA1C
CFI
MIEF1
MLKL
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NTRK1
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WNT5B

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