Expression patterns of risk genes associated with three evolutionarily relevant syndromes in rhesus macaque and human brains.

doi:10.1038/s41398-026-04198-w

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Article

Expression patterns of risk genes associated with three evolutionarily relevant syndromes in rhesus macaque and human brains.

Translational psychiatry - 25 Jun 2026

Karunakaran Kalyani B, Purushottam Meera, Balakrishnan N, Viswanath Biju, Amemori Ken-Ichi, Jain Sanjeev

Abstract excerpt

Depressive disorder (DD), Alzheimer's disease (AD), and schizophrenia (SZ) are evolutionarily relevant traits that disrupt neural networks supporting affect and cognition. While genome-wide association studies have identified risk-related genes for these diseases, how the expression of these genes compare across species remains unclear. In this study, we examined the spatial and temporal expression of ~2000...

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Topics

Animals
Macaca mulatta
Humans
Schizophrenia
Brain
Alzheimer Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Species Specificity

Female

Genome-Wide Association Study

Genetic Predisposition to Disease

Male

Biological Evolution

Gene Expression

Source

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Identifiers

PMID: 42350389
DOI: 10.1038/s41398-026-04198-w
PMCID: PMC13554215

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