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RpS12-mediated induction of the Xrp1short isoform links ribosomal protein mutations to cell competition.

Cell reports - 23 Jun 2026

Tsakiri Eleni, Potiri Myrto, Kontogiannidi Kyriaki, Douka Katerina, Kanakousaki Kiriaki, Vavouraki Nikoleta, Loizou Maria, Moulos Panagiotis, Skoulakis Efthimios M C, Samiotaki Martina, Kafasla Panagiota, Kiparaki Marianthi

Abstract excerpt

Cell competition, the context-dependent cell elimination phenomenon via short-range cell-cell interactions, was originally described in Drosophila, where heterozygous ribosomal protein (Rp+/-) mutant cells are outcompeted by wild-type neighbors. The transcription factor Xrp1 mediates most Rp+/- phenotypes, including reduced translation and competitiveness, yet how RpS12 induces Xrp1 was unclear. We show that...

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PMID: 42176268
DOI: 10.1016/j.celrep.2026.117380

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