Article

Innate immune signalling drives loser cell elimination during stem cell competition in the <i>Drosophila</i> testis

2020-03-06

Abstract excerpt

In the Drosophila testis, a group of stromal cells termed hub provides multiple niche signals for the surrounding germline and somatic stem cells. Stem cells of both populations compete for physical retention in the niche, and stem cell clones unable to transduce any one niche signal are rapidly eliminated by differentiation. We have recently mapped the transcriptomes of isolated somatic cyst stem cells and diffe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c8c4bb86-1cc0-5cc8-9ca4-7a5bb3c56b46
DOI: 10.1101/2020.03.05.979161

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Innate immune signalling drives loser cell elimination during stem cell competition in the <i>Drosophila</i> testisDOI 10.1101/2020.03.05.979161Read

An ancient defense system eliminates unfit cells from developing tissues during cell competition.Semantic proximity Read

The <i>Drosophila</i> TNF Eiger contributes to Myc super-competition independent of JNK activitySemantic proximity Read

Decoding the regulatory logic of the <i>Drosophila</i> male stem cell systemSemantic proximity Read

Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue.Semantic proximity Read

Hh signalling is essential for somatic stem cell maintenance in the Drosophila testis niche.Semantic proximity Read

Niche-dependent modular regulation of the stem cell transcriptome separates cell identity and potentialSemantic proximity Read

Transcriptional Repression of <i>reaper</i> by Stand Still Safeguards Female Germline Development in <i>Drosophila</i>Semantic proximity Read

Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling.Semantic proximity Read

Identifying a common cause of the loser cell status in Drosophila melanogasterSemantic proximity Read

Traffic jam functions in a branched pathway from Notch activation to niche cell fate.Semantic proximity Read

Escargot restricts niche cell to stem cell conversion in the Drosophila testis.Semantic proximity Read

The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche.Semantic proximity Read