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Article

RhoGEF2 overexpression induces cell competition dependent on Ptp10D, Crumbs and the Hippo signaling pathway.

Journal of cell science - 1 Oct 2025

Fahey-Lozano Natasha, Portela Marta, La Marca John E, Richardson Helena E

Abstract excerpt

In Drosophila melanogaster larval epithelial tissues, cells containing mutations in the apico-basal polarity protein, Scrib, are eliminated by cell competition when surrounded by wild-type cells. In scrib mutant cells, signaling mediated by the receptor-type tyrosine phosphatase Ptp10D upon engagement with its ligand Sas in the surrounding wild-type cells triggers cell competition via EGFR-Ras pathway inhibition...

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Identifiers

PMID: 40968980
DOI: 10.1242/jcs.264377
PMCID: PMC12579956

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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