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Genetic landscaping of cell competition uncovers two core pathways mediated by Xrp1 or Eiger/TNF in Drosophila.

Genetics - 6 May 2026

Matsumoto Ryo, Kanda Hiroshi, Kawasaki Aya, Nakamura Mai, Nagata Rina, Xie Haolin, Huang Xinyue, Okumura Ayumu, Miyoshi Keita, Kobayashi Tomoe, Matsuyama Makoto, Kondo Shu, Saito Kuniaki, Igaki Tatsushi

Abstract excerpt

Genetic studies in Drosophila have uncovered diverse molecules that drive cell competition, a quality control mechanism whereby less-fit cells are eliminated through interactions with fitter neighboring cells. This has raised the fundamental question of whether cell competition converges on shared molecular pathways, despite being initiated by distinct genetic alterations. To address this, we conducted a...

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PMID: 41807109
DOI: 10.1093/genetics/iyag067

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TNF

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