Article
A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition.
Developmental cell - 20 Aug 2018
Lee Chang-Hyun, Kiparaki Marianthi, Blanco Jorge, Folgado Virginia, Ji Zhejun, Kumar Amit, Rimesso Gerard, Baker Nicholas E
Abstract excerpt
Ribosomes perform protein synthesis but are also involved in signaling processes, the full extent of which are still being uncovered. We report that phenotypes of mutating ribosomal proteins (Rps) are largely due to signaling. Using Drosophila, we discovered that a bZip-domain protein, Xrp1, becomes elevated in Rp mutant cells. Xrp1 reduces translation and growth, delays development, is responsible for gene...
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