Article
A memory of eS25 loss drives resistance phenotypes.
Nucleic acids research - 27 Jul 2020
Johnson Alex G, Flynn Ryan A, Lapointe Christopher P, Ooi Yaw Shin, Zhao Michael L, Richards Christopher M, Qiao Wenjie, Yamada Shizuka B, Couthouis Julien, Gitler Aaron D, Carette Jan E, Puglisi Joseph D
Abstract excerpt
In order to maintain cellular protein homeostasis, ribosomes are safeguarded against dysregulation by myriad processes. Remarkably, many cell types can withstand genetic lesions of certain ribosomal protein genes, some of which are linked to diverse cellular phenotypes and human disease. Yet the direct and indirect consequences from these lesions are poorly understood. To address this knowledge gap, we studied in...
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