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Cell competition removes segmental aneuploid cells from <i>Drosophila</i> imaginal disc-derived tissues based on ribosomal protein gene dose

2021-03-06

Abstract excerpt

<h4>ABSTRACT</h4> Aneuploidy causes birth defects and miscarriages, occurs in nearly all cancers, and is a hallmark of aging. Individual aneuploid cells can be eliminated from developing tissues by unknown mechanisms. Cells with ribosomal protein ( Rp ) gene mutations are also eliminated, by cell competition with normal cells. Because Rp genes are spread across the genome, their copy number is a marker for chro...

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Literature Corpus work
bb46e0af-5f5a-5442-8a10-c3446c6eaa03
DOI
10.1101/2021.03.05.433802
Open publication

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Cell competition removes segmental aneuploid cells from <i>Drosophila</i> imaginal disc-derived tissues based on ribosomal protein gene doseDOI 10.1101/2021.03.05.433802
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