Genes affecting cell competition in Drosophila.

doi:10.1534/genetics.106.061929

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Article

Genes affecting cell competition in Drosophila.

Genetics - 1 Feb 2007

Tyler David M, Li Wei, Zhuo Ning, Pellock Brett, Baker Nicholas E

Abstract excerpt

Cell competition is a homeostatic mechanism that regulates the size attained by growing tissues. We performed an unbiased genetic screen for mutations that permit the survival of cells being competed due to haplo-insufficiency for RpL36. Mutations that protect RpL36 heterozygous clones include the tumor suppressors expanded, hippo, salvador, mats, and warts, which are members of the Warts pathway, the tumor...

Topics

Animals
Apoptosis
Cell Polarity
Cell Survival
Drosophila Proteins
Drosophila melanogaster
Genes, Insect
Genes, Tumor Suppressor
Genetic Testing
Heat-Shock Response
Hyperplasia
JNK Mitogen-Activated Protein Kinases
Mutation
Signal Transduction

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Identifiers

PMID: 17110495
DOI: 10.1534/genetics.106.061929
PMCID: PMC1800612

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