Article
Silencing the Drosophila ribosomal protein L14 gene using targeted RNA interference causes distinct somatic anomalies.
Gene - 27 Nov 2003
Enerly Espen, Larsson Jan, Lambertsson Andrew
Abstract excerpt
The Drosophila Minutes are haploinsufficient mutations that are defective in ribosomal protein (rp) production, resulting in short, thin bristles, delayed development and recessive lethality. In a Minute fly, the amount of rp gene messenger RNA (mRNA) is reduced to >or=50% of the normal amount of gene product, and becomes rate limiting for ribosome biogenesis, cell proliferation and growth. Haploinsufficiency...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.