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Ribonucleotide-Modified Primer Overlapping Blocker Elongation (PROBE) Assay for Highly Specific Mutation Detection.

Analytical chemistry - 9 Jun 2026

Zhao Yongjuan, Wang Ziyan, Zhang Min, Zhao Xiuli, Yan Beibei, Ma Yingying, Song Zhi-Gang, Wan Zhenzhou, Zhang Chiyu

Abstract excerpt

Single-nucleotide variants (SNVs) are the most common type of genetic variation and are associated with some diseases. Accurate detection of SNVs is of great significance in multiple fields. Despite the rapid development of SNV detection technologies, most methods suffer from limitations in detection specificity, which may lead to false positive results, especially for low-frequency SNVs. Here, we report a novel...

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Identifiers

PMID: 42175894
DOI: 10.1021/acs.analchem.6c01601

Genes

ADH1B
ALDH2
C3

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