Modified Unit-Mediated Strand Displacement Reactions for Direct Detection of Single Nucleotide Variants in Active Double-Stranded DNA.

doi:10.1021/acsnano.4c01511

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Article

Modified Unit-Mediated Strand Displacement Reactions for Direct Detection of Single Nucleotide Variants in Active Double-Stranded DNA.

ACS nano - 14 May 2024

Yu Hongyan, Han Xiaole, Wang Weitao, Zhang Yangli, Xiang Linguo, Bai Dan, Zhang Li, Weng Zhi, Lv Ke, Song Lin, Luo Wang, Yin Na, Zhang Yaoyi, Feng Tong, Wang Li, Xie Guoming

Abstract excerpt

Accurate identification of single nucleotide variants (SNVs) in key driver genes holds a significant value for disease diagnosis and treatment. Fluorescent probes exhibit tremendous potential in specific, high-resolution, and rapid detection of SNVs. However, additional steps are required in most post-PCR assays to convert double-stranded DNA (dsDNA) products into single-stranded DNA (ssDNA), enabling them to...

Topics

Polymorphism, Single Nucleotide
Humans
DNA
Colorectal Neoplasms
Polymerase Chain Reaction
Fluorescent Dyes
DNA, Single-Stranded

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Identifiers

PMID: 38701333
DOI: 10.1021/acsnano.4c01511

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