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Article

A universal approach for mutation identification with a DNA probe-enzyme combination platform.

Analytical methods : advancing methods and applications - 21 Aug 2025

Li Bo, Wang Yufei, Zhong Yan, Xin Hui, Li Zheng, Xu Chang, Wang Chunyan

Abstract excerpt

The development of rapid, and highly specific approaches for mutation detection is crucial for clinical diagnosis, since gene mutations are closely related to the progression of various diseases. In this study, we developed a convenient nucleic acid probe-promoted enzymatic reaction to assist in the sensitive detection of mutations in clinical samples. A set of DNA probes were designed to achieve preliminary...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40793936
DOI: 10.1039/d5ay00733j

Genes

BRAF
EGFR
TP53

Variants

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