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In Situ Amplified Mutational mRNA Imaging Using a Spatially Confined CRISPR Nanoplatform.

Angewandte Chemie (International ed. in English) - 27 Jul 2026

Zhao Wen, Zheng Ziyue, Li Rui, Xie Haojie, Yu Haiyun, Zhang Yongyuan, Wu Yonghua, Yang Yunqing, Zhang Zhenzhong, Gao Hua, Li Yanan, Zhang Kaixiang

Abstract excerpt

Highly sensitive spatial analysis of RNA mutations is essential for understanding cellular heterogeneity and disease mechanisms. Herein, we developed an integrated CRISPR/Cas13a-based nanoprobe system for rapid detection of RNA in tissue sections (Integrated CRISPR/Cas13a-based RNA Rapid Detection, InCasRD). Unlike conventional "always-on" probes that rely on accumulated probe hybridization, InCasRD leverages the...

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PMID: 42233593
DOI: 10.1002/anie.7088080
PMCID: PMC13411367

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