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Article

Aneuploidy drives genomic instability in yeast.

Science (New York, N.Y.) - 19 Aug 2011

Sheltzer Jason M, Blank Heidi M, Pfau Sarah J, Tange Yoshie, George Benson M, Humpton Timothy J, Brito Ilana L, Hiraoka Yasushi, Niwa Osami, Amon Angelika

Abstract excerpt

Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms...

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Identifiers

PMID: 21852501
DOI: 10.1126/science.1206412
PMCID: PMC3278960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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