Chromosome 5q deletion drives evolution of aneuploidy in myeloid neoplasms with complex karyotype.

doi:10.1182/blood.2025031996

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Article

Chromosome 5q deletion drives evolution of aneuploidy in myeloid neoplasms with complex karyotype.

Blood - 27 Aug 2026

Creamer J Philip, Ray Suhita, Stewart Sintra, Gulsuner Suleyman, Saliba Antoine N, Wu Jieya, Huang Frank Y, Leppä Aino-Maija, Wang Bofei, Abbas Hussein A, Abkowitz Janis L, Appelbaum Jacob S, Kaufmann Scott H, Becker Pamela S, Trumpp Andreas, Jobanputra Vaidehi, Fang Min, Swisher Elizabeth M, Doulatov Sergei

Abstract excerpt

ABSTRACT: Clonal acquisition of multiple chromosomal abnormalities in hematopoietic stem and progenitor cells (HSPCs) is a hallmark of high-risk acute myeloid leukemia with complex karyotype (AML-CK). AML-CK is associated with TP53 mutations and chromosome 5q deletions [del(5q)]; however, the drivers and clonal trajectories of aneuploid evolution in HSPCs remain unknown. We developed a patient-derived induced...