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Complex Genomic Alterations in TP53-Mutated Myelodysplastic Syndrome and Acute Myeloid Leukemia Involving EPOR/JAK2 Amplification, ERG Copy Gains, and TCF3 Deletion.

Genes, chromosomes & cancer - 1 Aug 2026

Gindina T L, Riumin S S, Barkhatov I M, Gracheva T Yu, Bug D S, Babenko E V, Morozova E V, Tsvetkov N Yu, Mamaev N N, Kulagin A D

Abstract excerpt

BACKGROUND: Myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML) harboring TP53 mutations are defined by extreme genomic instability, complex karyotypes (CK), and poor prognosis. While large-scale chromosomal imbalances are common in CK-MDS/AML, the synergy between focal amplifications of signaling drivers and the disruption of transcriptional regulators remains poorly elucidated. METHODS: We...

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Source

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Identifiers

PMID: 42568049
DOI: 10.1002/gcc.70159
PMCID: PMC13451528

Genes

JAK2
TP53
EPOR
TCF3
ERG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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