Article
Recurrent genetic defects on chromosome 5q in myeloid neoplasms.
Oncotarget - 24 Jan 2017
Hosono Naoko, Makishima Hideki, Mahfouz Reda, Przychodzen Bartlomiej, Yoshida Kenichi, Jerez Andres, LaFramboise Thomas, Polprasert Chantana, Clemente Michael J, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Sanada Masashi, Cui Edward, Verma Amit K, McDevitt Michael A, List Alan F, Saunthararajah Yogen, Sekeres Mikkael A, Boultwood Jacqueline, Ogawa Seishi, Maciejewski Jaroslaw P
Abstract excerpt
BACKGROUND: Deletion of chromosome 5q (del(5q)) is the most common karyotypic abnormality in myeloid neoplasms. MATERIALS AND METHODS: To define the pathogenic molecular features associated with del(5q), next-generation sequencing was applied to 133 patients with myeloid neoplasms (MDS; N = 69, MDS/MPN; N = 5, sAML; N = 29, pAML; N = 30) with del(5q) as a sole abnormally or a part of complex karyotype and results...
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