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Article

The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.

Communications biology - 23 Oct 2020

Pei Yu-Fang, Liu Yao-Zhong, Yang Xiao-Lin, Zhang Hong, Feng Gui-Juan, Wei Xin-Tong, Zhang Lei

Abstract excerpt

Appendicular lean mass (ALM) is a heritable trait associated with loss of lean muscle mass and strength, or sarcopenia, but its genetic determinants are largely unknown. Here we conducted a genome-wide association study (GWAS) with 450,243 UK Biobank participants to uncover its genetic architecture. A total of 1059 conditionally independent variants from 799 loci were identified at the genome-wide significance...

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Identifiers

PMID: 33097823
DOI: 10.1038/s42003-020-01334-0
PMCID: PMC7585446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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