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Article

Identifying Rare Genetic Determinants for Improved Polygenic Risk Prediction of Bone Mineral Density and Fracture Risk.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2023

Lu Tianyuan, Forgetta Vincenzo, Zhou Sirui, Richards J Brent, Greenwood Celia Mt

Abstract excerpt

Osteoporosis and fractures severely impact the elderly population. Polygenic risk scores for bone mineral density have demonstrated potential clinical utility. However, the value of rare genetic determinants in risk prediction has not been assessed. With whole-exome sequencing data from 436,824 UK Biobank participants, we assigned White British ancestry individuals into a training data set (n = 317,434) and a...

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Source

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PMID: 37830501
DOI: 10.1002/jbmr.4920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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