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Article

APOL1 risk genotypes influence DNA methylation across multiple genomic elements in APOL1-APOL4- MYH9 region in African Americans.

Clinical epigenetics - 20 May 2026

Li Yang, Bozack Anne K, Schlosser Pascal, Rhee Eugene P, Surapaneni Aditya, Waterhölter Alex, Rodriguez-Hernandez Zulema, Ruggles Kelly V, Coresh Josef, Grams Morgan E

Abstract excerpt

BACKGROUND: Epigenetic modification of the APOL1 gene carrying risk alleles (G1 and G2) may represent a therapeutic strategy for APOL1-related kidney diseases. However, DNA methylation changes associated with APOL1 have not been thoroughly characterized. METHODS: We conducted an epigenome-wide association study (EWAS) of APOL1 risk alleles in 399 African Americans with chronic kidney disease (CKD) from the...

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Share to Apolipoprotein L1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42163362
DOI: 10.1186/s13148-026-02147-4
PMCID: PMC13386890

Genes

APOL1
MYH9
APOL4
ACR
APOL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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