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Article

African ancestry-derived APOL1 risk genotypes show proximal epigenetic associations.

BMC genomics - 8 May 2024

Breeze Charles E, Lin Bridget M, Winkler Cheryl A, Franceschini Nora

Abstract excerpt

Apolipoprotein L1 (APOL1) coding variants, termed G1 and G2, are established genetic risk factors for a growing spectrum of diseases, including kidney disease, in individuals of African ancestry. Evidence suggests that the risk variants, which show a recessive mode of inheritance, lead to toxic gain-of-function changes of the APOL1 protein. Disease occurrence and presentation vary, likely due to modifiers or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38714935
DOI: 10.1186/s12864-024-10226-0
PMCID: PMC11077761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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