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Epigenetic associations with kidney disease in individuals of African ancestry with APOL1 high-risk genotypes and HIV.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 28 Apr 2025

Hung Rachel K Y, Costeira Ricardo, Chen Junyu, Schlosser Pascal, Grundner-Culemann Franziska, Booth John W, Sharpe Claire C, Bramham Kate, Sun Yan V, Marconi Vincent C, Teumer Alexander, Winkler Cheryl A, Post Frank A, Bell Jordana T

Abstract excerpt

BACKGROUND: Apolipoprotein L1 (APOL1) high-risk variants are major determinants of chronic kidney disease (CKD) in people of African ancestry. Previous studies have identified epigenetic changes in relation to kidney function and CKD, but not in individuals with APOL1 high-risk genotypes. We conducted an epigenome-wide analysis of CKD and estimated glomerular filtration rate (eGFR) in in people of African...

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Apolipoprotein L1
Black People
DNA Methylation
Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glomerular Filtration Rate

Renal Insufficiency, Chronic

Source

Open in PubMed Open full text

Identifiers

PMID: 39448372
DOI: 10.1093/ndt/gfae237
PMCID: PMC12035534

Genes

APOL1
SCARB1
CD4
CSRNP1
DNAJC5B
FRMD4A
RAB38

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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